is a bio-restitutive soft filler that induces natural restoration of pre-aging conditions, by promoting the production of type I collagen in human fibroblasts.
KARISMA FACE Rh Collagen® is an injectable MD Class III, that contains:
KARISMA FACE Rh Collagen® formulation, thanks to the presence of the amino acid chain R-polypeptide α1 in synergy with high molecular weight hyaluronic acid and carboxymethyl cellulose, fights skin laxity by creating a tightening effect.
Cellular stimulation promoted by KARISMA FACE Rh Collagen® restores firmness and structure to the skin, with a gradual, visible and lasting improvement.
The R polypeptides α1 chain of type I collagen contained in KARISMA FACE Rh Collagen® (a new patented technology) is synthesized by transgenic silkworm and secreted in their cocoon.
Hydroxylated α1 chain of recombinant type I collagen acts as a precursor in the synthesis of endogenous collagen.
KARISMA FACE Rh Collagen® increases the production of procollagen type I C-Peptide in fibroblasts.
The R polypeptides α1 chain of type I collagen contained in KARISMA FACE Rh Collagen® (a new patented technology) is synthesized by transgenic silkworm and secreted in their cocoon.
Hydroxylated α1 chain of recombinant type I collagen acts as a precursor in the synthesis of endogenous collagen.
Hyaluronic Acid is an integral component of the extracellular matrix in most mature organisms and is found naturally within most body tissues, including the skin.
The therapeutic effect of hyaluronic acid-based preparations directly depends on the molecular weight of this biopolymer.
Carboxymethylcellulose (CMC) is a biosynthetic substance used as an excipient for many drugs, as a component of adhesion membranes in abdominal surgery and as a carrier in many dermal fillers.
The non-bacterial and non-animal origin of CMC and its anti-inflammatory activity give this substance unique properties
CMC has an anti-aging effect in the dermis: it inhibits the action of the hyaluronidase enzyme and preserves the endogenous hyaluronic acid, which, while remaining in the tissues, continues to perform its hydration and tissue repair activity in depth.
CMC also slows down the action of MMPs (Matrix MetalloProteinasis), which are responsible of collagen type I degradation and unwinding of the triple helix chains.
The therapeutic effect of hyaluronic acid-based preparations directly depends on the molecular weight of this biopolymer.
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